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Temozolomide is used to treat cancer by interfering with the growth and spread of cancer cells. It is often used in conjunction with radiation therapy and used when other cancer drugs have not been successful.

Temozolomide is often taken on 28-day treatment cycles. Dosing schedule may also depend on radiation treatment. Follow doctor’s instructions carefully. Size and color of temozolomide pills may differ between treatment cycles. Take with full glass of water. Take entire daily dose at the same time on each dosing day. If you vomit after taking this drug, don’t take another capsule until your next scheduled dose. As dosage is based on height and weight, inform doctor if height or weight changes. Contact doctor if you miss a dose.


Don’t take temozolomide if you are allergic to it or dacarbazine. Do not open pill – medicine from opened pill may be dangerous if in contact with skin, nose, or mouth. Avoid people who are sick/infected while on this medication, and contact doctor if you suspect an infection. Avoid activities that may put you at risk of bleeding or injury, and use extra caution when shaving or brushing teeth. Caregivers should wear gloves when in contact with patient’s bodily fluids. Wash soiled laundry separate from other laundry. Inform healthcare provider of all your conditions, allergies, and medications you take as this drug may interact with others, especially valproic acid and steroid medicine.

Side Effects

Temozolomide use may increase risk of developing certain types of bone marrow cancer. May cause stomach upset which may affect your dosing schedule. May lower blood cell counts used to fight infections and clot blood. Get immediate medical help if you have signs of an allergic reaction. Contact doctor at once if you encounter effects such as: convulsions, chest pain, wheezing, chest discomfort, shortness of breath, dry cough, easy bruising/bleeding, purple/red pinpoint spots beneath skin, symptoms of low blood ceel counts, symptoms of liver problems. Other possible side effects include: nausea and vomiting, appetite loss, bruising, rash, loss of movement on one side of body, diarrhea, upset digestive system, headache, fatigue, memory problems, dizziness, coordination problems, weakness, insomnia, flu/fever symptoms, hair loss.

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