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Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
Difference between Brand & Generic?


Activella contains the medicinal ingredient called estradiol, which is a form of estrogen, a female sex hormone that governs many of the bodily processes in the female body. The other medicinal component found in Activella is called norethindrone, which is a form of progesterone, another female hormone that regulates the process of ovulation and menstruation in the female body.

Activella is used as treatment with other medications to relieve the symptoms associated with menopause such as hot flashes and vaginal changes while preventing osteoporosis as well.

Activella is a prescription medication and should be taken strictly as directed by your prescribing doctor.

Taking estradiol has a potential risk of developing a condition that may ultimately result in uterine cancer. If you notice any abnormal bleeding in your vagina while on treatment with Activella, you should inform your doctor of this immediately.

During treatment, you should have regular consultations with your doctor to monitor your progress in order to judge whether you should continue or stop treatment. Make it a practice to self-examine your breasts for lumps every month and schedule a mammogram annually while using Activella.


Before starting treatment with Activella, you should consult with your doctor regarding your medical history, especially if you have had unusual vaginal bleeding that remains unchecked, liver disease, a bleeding disorder, heart attack, stroke, blood clot, or cancer of the breast, uterus, cervix, or vagina.

To ensure your safety during treatment, also inform your doctor if you have had a history of heart disease, liver problems, jaundice, hereditary angioedema, epilepsy, kidney disease, gallbladder disease, asthma, migraines, lupus, porphyria, endometriosis or uterine fibroid tumors, thyroid disorder, or high calcium levels in the blood.

Side Effects

There are both common (less serious) and uncommon (serious) side effects associated with the use of Activella. If you have any concerns about any side effects you are experiencing, contact your doctor.

Some common side effects of Activella may include:

  • Nausea
  • Vomiting
  • Bloating
  • Stomach cramps
  • Fluid retention
  • Headache
  • Breast pain
  • Thinning scalp hair
  • Vaginal itching or discharge
  • Menstrual cycle changes
  • Breakthrough bleeding

Uncommon, yet serious side effects may include:

  • Heart attack symptoms
  • Stroke symptoms
  • Blood clot symptoms
  • Stomach swelling
  • Tenderness
  • Jaundice
  • Cognitive impairment
  • Confusion
  • Abnormal behavior
  • Abnormal bleeding
  • Pelvic pain
  • Breast lump
  • High calcium levels in the blood

If you notice any uncommon side effects listed here, seek emergency medical assistance and call your doctor right away.


Can I smoke cigarettes during treatment with Activella?

Do not smoke when using Activella as it may seriously increase the potential risk of blood clots, stroke, or a heart attack.

How should I store my Activella when I’m not using it?

When it’s time to store your Activella medication, keep them in a cool, dry, and dark environment safely out of reach from young children and pets.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-202-1513 and a member of our CareTeam will be happy to assist you.

Call 1-877-202-1513
* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

Real Customers, Honest Reviews

very pleased with your service considering the pandemic.
Thomas January 20, 2021

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Michael January 19, 2021

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Everyone there is always professional and courteous. I have memory issues so I love that y'all call to see if I need another Rx shipped
Lisa January 15, 2021

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Easy and affordable
Patrick January 13, 2021

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Having been a customer for 5 years, more or less, I have been pleasantly surprised with the level of service and prices. Recently, I failed to receive an order after shipment, it has been fully rectified. thank you!
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I had a very good experience.
Timothy December 31, 2020

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We have been ordering for several years and have been pleased with the service.
Raylene December 31, 2020

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I love Canada Med Stop and recommend you to my friends anytime I get a chance.
John December 30, 2020

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The actual ordering process was timely, courteous, and easy. Shipping time frames remain a problem: the Order shipped on 10December2020 and has not yet been received. Actual receipt of my Orders almost always approaches 30 day from the shipping date...and in [several] instances, approached 45 days out from the shipping date.
Michael December 31, 2020

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as close to perfect as possible
Martin March 16, 2020
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