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Not used on its own, entacapone works with carbidopa and levodopa to treat symptoms of Parkinson’s disease. Some of the symptoms it treats are stiffness, tremors, muscle spasms, and poor muscle control.

Entacapone needs to work in tandem with carbidopa and levodopa at the right dose, so be sure to follow your doctor and prescription label’s directions.

You can either take the medication with or without food. Food is recommended to help prevent any risk of nausea. But no matter your preference for food intake, you should still drink lots of liquids while on this medication.

After taking your dose, store the remaining medication away in an area at room temperature away from moisture and heat.


This medication may make you fall asleep without warning during your regular daytime activities. This drowsiness can happen even when you’re alert, so try to avoid activities that require alertness like driving. And call your doctor as soon as possible if you are experiencing this situation.

Side Effects

Side effects for entacapone include drowsiness, nausea, diarrhea, and dry mouth.

Call your doctor right away if you notice serious symptoms such as: agitation, unusual thoughts or behavior, hallucinations, stiff muscles, high fever, tremors, severe or ongoing diarrhea, restless muscle movements, or unexplained muscle pain, tenderness, or weakness.

To lower your risk for some of these side effects, try to avoid alcoholic beverages. Drinking alcohol can increase the likelihood of entacapone side effects.

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Sally D

March 14, 2023

Meds arrived quickly, probably because they came from Canada. In good shape.

Dwayne M

March 14, 2023


Pamela V

March 14, 2023

I am always very pleased with being able to order from Medicare will only cover half the year and then I am in the donut hole....Xarelto works very well for my A-Fib and because of you I can use all year long

Nancy M

March 14, 2023

The representatives are excellent in customer service. I have used this drug company for many years. The price of my prescription is the reason I use Canada Meds.

Carolyn W

March 14, 2023

good interaction and very helpful

Carol K

March 14, 2023

I have used Canada Med Stop for about 10 years. My orders have always been efficiently handled and approved by my doctors. Plus the cost of my prescription has been a 3rd of the cost in the US.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

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Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.