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Sumatriptan is used to treat headaches. It narrows vessels around the brain and reduces bodily substances that can trigger headaches and migraine symptoms. It is used to treat migraines and cluster headaches. It cannot be used to prevent potential attacks. It should not be used to treat tension headaches or headaches that cause loss of movement on one side of the body. Injected sumatriptan is not approved for patients under 18.

Sumatriptan Injection Instructions:

Used as-needed. Take as soon as you feel symptoms. Do not use more than prescribed dose. Injection is injected underneath skin. Do not use if medicine in vial looks cloudy, has particulates, or has changed colors. Do not inject more than twice in 24 hours. If symptoms do not completely go away, call doctor before using another injection. Use syringes only once and dispose of it properly following local laws. Dispose medicine after expiration date passes.


Do not use within 24 hours before/after another migraine medicine, including tablet form of the sumatriptan, or before/after an ergot medicine. Do not use if you’ve taken a MAO inhibitor in the last 14 days. Inform doctor of all drugs you take and medical history, especially cardiovascular problems (including “mini-strokes”), liver problems, if your headache feels different from usual migraines, and if you have risk factors for coronary artery disease such as diabetes, smoking, and family history. Do not breast-feed within 12 hours after taking sumatriptan.

Side Effects

Get emergency help if you suspect an overdose or allergic reaction. Cease use and contact doctor immediately if you encounter serious effects such as: sudden severe stomach pain, irregular pulse, shortness of breath, chest pain, seizure, circulation problems in legs and feet, heart attack symptoms, signs of excessive serotonin levels, symptoms of increased blood pressure, symptoms of stroke. Other effects may include: numbness and tingling, warmth and burning, pressure or heavy feeling, dizziness, drowsiness, fatigue, neck pain, stiffness, pain/redness at site of injection. May cause serotonin syndrome. May interact with herbs, opioids, psychiatric medications, stimulants, and more.

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