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Prescription Required
IMPORTANT NOTE: A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.
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Premarin Cream contains a combination of estrogen hormones. Estrogen is the primary female sex hormone produced by the ovaries that are responsible for many of the core processes in the female body.

This medication is applied directly inside the vagina to treat menopausal symptoms in females such as dryness, burning, irritation, and pain during sexual intercourse.

There are other uses for Premarin Cream that may not be mentioned here.

It is imperative that you use Premarin Cream the way that you were instructed to by your prescribing doctor. Importantly, not using the cream in greater or lesser doses or for a longer period of time than instructed to.

When taking conjugated estrogens, the possibility of developing a condition that has a chance of resulting in uterine cancer is increased. Your physician may deem necessary to prescribe you for a progestin to use in combination with Premarin Cream to mitigate this risk. If you notice any abnormal bleeding in the vagina, you should inform your physician of this at once.

Do not apply Premarin Cream using your fingers and only use the vaginal applicator provided to you. After using the applicator, take it apart and cleanse it thoroughly with warm water with the use of a light soap. Avoid using extremely hot or boiling water, as the plastic may lose its shape and intended functionality.

Get routine checks with your doctor to measure if the Premarin Cream is working effectively to relieve your symptoms and whether this medication is right for you. Make it a monthly routine to check your breasts for lumps and schedule mammograms on a regular basis.

You may need to stop your treatment if you are scheduled to have a major surgical operation or need to be on long-term bed rest. Always inform any doctor or surgeon that you are using Premarin Cream.

When not using this medication, always keep it out of the reach of young children and pets in a cool and dry environment.


Take precautions before using Premarin Cream. If you had a medical history of abnormal bleeding in the vagina that has not been looked at, liver disease, heart attack, stroke, blood clot, hormone-related cancer, breast cancer, vaginal cancer, uterine/cervical cancer or if you have a higher risk of developing blood clots because of a heart problem or a family history of blood disorder.

If you are pregnant, you should not use Premarin Cream. If you think you might be pregnant, inform your doctor immediately.

If you are not yet past menopause, speak to your doctor about the best contraceptive options available to you during your treatment with Premarin Cream. This medication has a possibility of weakening the latex material used in condoms, diaphragm, or cervical cap.

While using Premarin Cream, you are at risk of blood clots, a stroke, or heart attack, and an even greater risk if you have a history of high blood pressure, diabetes, high cholesterol levels, if you are overweight, or if you smoke.

Estrogen may increase the likelihood of developing heart disease, stroke, breast cancer, uterine cancer, ovarian cancer, or dementia. It is also likely to slow the production of breast milk and you should speak to your doctor if you are currently breastfeeding.

Inform your doctor of your complete medical history to determine if Premarin Cream is right for you, especially if you have had a hysterectomy, heart disease, liver problems, jaundice, kidney disease, gallbladder disease, asthma, epilepsy, migraines, lupus, endometriosis, hereditary angioedema, porphyria, thyroid disorder, or high calcium levels in your blood.

Premarin Cream is only approved to be used by adults over the age of eighteen.

Side Effects

If you notice symptoms such as hives, breathing difficulties, face swelling, lips swelling, tongue swelling, or throat swelling while using Premarin Cream, you may be having an allergic reaction. Call for emergency medical assistance.

Contact your doctor immediately if you notice signs of a heart attack, stroke, blood clot, or high calcium levels in your blood. These symptoms consist of but are not limited to, chest pain, pressure in the chest, jaw pain, shoulder pain, nausea, sweating, numbness, weakness, severe headache, slurring of words, cognitive impairment, vision loss, short of breath, tenderness in stomach, jaundice, memory problems, confusion, unusual behavior, abnormal vaginal bleeding, pelvic pain, a lump in your breast, vomiting, constipation, increased thirst or increased urination, muscle weakness, bone pain, or fatigue.

More common side effects from the use of Premarin Cream are:

  • Headaches
  • Pain in the pelvis
  • Feeling warm
  • Redness in your skin
  • Tingly sensation
  • Breast pain
  • Vaginal itching
  • Vaginal discharge
  • Breakthrough bleeding
  • Changes in your menstrual cycles

This is not a complete list of all possible side effects you may experience. You should consult with your physician if you have any questions or concerns.


Is there anything I should avoid while using Premarin Cream?

Try not to smoke cigarettes. This has been known to immensely increase the possibility of developing blood clots, having a stroke or a heart attack during the use of Premarin Cream.

What should I do if I missed my dose?

Try to take the dose you missed when you realize. Unless it is close to the time for your next dose. Never try to make up for a dose you missed by taking more than you are prescribed to take.

A valid Prescription is required to be mailed or faxed to complete this order. I acknowledge that I will need to be contacted to complete a health profile before my order is shipped.

Your Lowest Price, Guaranteed

Our goal is to bring you the most affordable medication. If you find a lower price advertised by another website or your local pharmacy, we’ll match that price or beat it by 10% of the difference.* Call us at 1-877-202-1513 and a member of our CareTeam will be happy to assist you.

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* Some exceptions may apply
Some exceptions may apply. To qualify for price matching, competitors must meet our standards for patient safety. Advertised prices must be for medication of the same type, strength, quantity, and form.

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Raymond February 26, 2020

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My order always arrives efficiently & correctly. I am totally satisfied with this company.
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Terrific service, easy to order, great prices, and delivered on time.
Carol February 25, 2020

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It is always easy ordering and refilling prescriptions through this company. They remind you when your Rx is ready for refill. I highly recommend them.
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My order was handled professionally and efficiently.
Robert (Edd) February 25, 2020

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As always, service was excellent
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i find the customer service outstanding every time i call to refill a prescription.
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I like that the customer reps at Canada Med Stop remind me when I am needing more medication, and that they spend time with me to explain the order, shipping, etc. They are always courteous and patient.
Marcia February 25, 2020

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Great , no problems at all. Thank You Lisa
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