Sinemet is a combination medication commonly used to treat symptoms of Parkinson’s disease.

If you take levodopa, stop taking it at least 12 hours before taking Sinemet. Follow all prescription label instructions and your doctor’s instructions carefully. This drug can be taken with or without food. Take at regular intervals. It may take several weeks for symptoms to improve. Notify your doctor if medication’s effects seem to wear off quickly between doses. Do not stop taking this drug suddenly.

Do not use Sinemet if you have narrow-angle glaucoma or if you have used a MAO inhibitor in the past 14 days. Use caution when driving or doing anything that requires alertness. Avoid getting up too quickly. Avoid iron supplements and a high-protein diet.

Find emergency medical care if you experience symptoms of an overdose, allergic reaction, or symptoms including (but not limited to) the following: uncontrolled muscle movements, severe vomiting/diarrhea, tremors, confusion, hallucinations, depression, suicidal thoughts, symptoms of a severe nervous system reaction. More common side effects include: muscle contractions, nausea. Other side effects include: excessive daytime sleepiness, increased libido, dark sweat/urine/saliva.