Estradiol is a form of estrogen used to treat menopause symptoms, prevent osteoporosis, treat low estrogen levels, and treat certain types of breast and prostate cancer.

Follow doctor and label instructions. Dispose of syringes safely in accordance with local law. Avoid open flames and smoking until spray form of medication has dried. Do not apply lotion or sunscreen over area for at least 1 hour. Inform all medical personnel you may encounter that you are taking this drug.

Do not use if pregnant or if you’ve had a heart attack or stroke, liver disease, undiagnosed vaginal bleeding, bleeding disorder, or breast/uterus/cervix/vagina cancer. Inform doctor of medical history and medications used before taking. Avoid smoking and grapefruit products.

Get help immediately and inform physician if you experience a serious side effect, including: heart attack or stroke symptoms, signs of a blood clot, swelling/tenderness in stomach, jaundice, memory problems, unusual vaginal bleeding and pelvic pain, lump in breast, nausea and vomiting, and increased thirst/urination. Other common side effects include nausea and vomiting, insomnia, cold symptoms, weight gain, headache, back pain, skin rash or skin darkening, vagina itching/discharge, thinning scalp hair, and breast pain.